WANI Dictionary

Vector copy number (VCN)

A vector copy number (VCN) is the number of vector molecules usually shown with a unit of copies/one host cell.

The VCN is an important parameter that affects the amount of expressed protein in heterologous protein expression systems.

Definitions in the literature

• A critical parameter is the vector copy number (VCN) which measures the genetic dose of a transgene present in gene-modified cells [1].