WANI Dictionary

Glyceroneogenesis

Glyceroneogenesis is the synthesis of glycerol-3-phosphate (G3P) from precursors other than glucose and glycerol.

Several important features of glyceroneogenesis include:

• G3P is a substrate of triacylglycerol (TAG) synthesis.
• Major precursors are lactate, pyruvate, alanine, and intermediates of the TCA cycle.
• Glyceroneogenesis is the dominant pathway for G3P synthesis in rat, which contributes about 90% of G3P production [1].

Definitions in the literature

• Glyceroneogenesis, the de novo synthesis of G-3-P from precursors other than glucose and glycerol (i.e. pyruvate, lactate, alanine, and citric acid cycle anions) has long been suggested as a potential pathway for triglyceride glycerol formation in adipose tissue [1].